Abstract
A series of novel guanidine-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immunosuppressive and antiviral therapy. The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Guanidine / analogs & derivatives*
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Guanidine / chemical synthesis*
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Guanidine / pharmacology
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Humans
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IMP Dehydrogenase / antagonists & inhibitors*
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Indicators and Reagents
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Structure-Activity Relationship
Substances
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Antiviral Agents
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Enzyme Inhibitors
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Indicators and Reagents
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IMP Dehydrogenase
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Guanidine